Publications (6)
Santé Humaine
Nutrition et alimentation
Introduction
Le contrôle des aliments reste un élément clé de leur qualité. En effet, l’absence de cette action peut impacter la santé des populations. L’objectif de cette étude était d’évaluer la conformité des denrées alimentaires au Laboratoire National de Santé Publique (LNSP) de 2018 à 2023.
Méthodes
L’étude était de type transversal descriptif et s’est déroulée en Avril 2025. Elle a porté sur l’exploitation des archives électroniques des résultats d’analyse générée au Laboratoire National de Santé Publique de 2018 à 2023. Ces données ont ensuite été saisies et traitées à l’aide du logiciel EXCEL 2021.
Résultats
Le LNSP a généré 1053 certificats d’analyse. Parmi ces certificats, 469 (44%) certificats étaient conformes, 301 (29%) certificats étaient non-conformes et 283 (27%) certificats étaient non-applicables (NA). Le statut des échantillons était significatif en 2022 avec 74 (36%) certificats non-conformes, en 2023 avec 184 (57%) certificats conformes et en 2019, 2021, 2022 et 2023 avec environ 30% des certificats non-applicables.
Conclusion
Les autorités doivent mettre en place les spécifications de conformité des denrées alimentaires locales.
Message de santé publique
Renforcer les contrôles des denrées alimentaires pour garantir la sécurité sanitaire des aliments sur le marché.
📅 2025
📰 Bulletin de Santé Publique de Côte d’Ivoire
Santé Humaine
Résistance aux antimicrobiens
La vancomycine est le traitement de référence des infections à staphylocoques multirésistants. Toutefois, en cas d’impossibilité le linézolide, chef de file de la classe des oxazolidinones et mis sur le marché au début des années 2000 constitue une alternative de choix. En Côte d’Ivoire, il n’est utilisé depuis 2024 que dans la prise en charge de la tuberculose multirésistante, il a été possible de recevoir du linézolide sous forme de solution pour perfusion. Ainsi, 9 patients ont pu en bénéficier. Il s’agissait de patients atteints d’infections à staphylocoques multirésistants, pour lesquels il y avait peu d’alternatives. Les situations étaient variées, tant en termes d’âge (aussi bien des enfants que des patients de gériatrie), que de localisation du foyer infectieux (infections ostéoarticulaires, pleuropulmonaires, septicémies). Mais tous les cas ont été traités avec succès. Cette série de cas confirme ainsi l’intérêt de l’introduction du linézolide dans l’arsenal thérapeutique, à condition qu’il soit utilisé comme antibiotique de réserve pour préserver son efficacité.
📅 2025
📰 Revue Africaine d’Anesthésiologie et de Médecine d’Urgence (RAMUR)
Santé Humaine
Maladies infectieuses et tropicales
Paludisme
Quinoline core antimalarials are a major class used for the management of uncomplicated malaria in combination with artemisinin derivatives. Moreover,
despite its adverse effects, Quinine remains the reference molecule in the treat-ment of cerebral malaria due to Plasmodium falciparum. This class also contains molecules such as Mefloquine used in the prevention of malaria. In addition,
synthetic derivatives are more manageable with greater therapeutic margins and fewer adverse effects. They have an interest in avoiding the spread of resistance, especially with derivatives possessing gametocytocidal activities. With the presence of a chloroquine-resistant strain of Plasmodium, the use of synthetic derivatives
as monotherapy is prohibited to avoid the spread of resistance in this class. In this chapter, we propose to present the class of antimalarials with a quinoline nucleus under its pharmacochemical aspects as well as the prospects for its development to preserve and improve the effectiveness of its representatives in the management of malaria.
📅 2023
📰 IntechOpen Book Series
Santé Humaine
Maladies infectieuses et tropicales
Aims: The general objective assigned to this work was to contribute to the pharmacochemical development of new antifungal drugs derived from 6-Chloroimidazo [1,2-a]pyridine.This preliminary study was conducted on Candida parapsilosis, which is an increasingly difficult organism to treat.
Methodology: The imidazo [1,2-a] pyridinylacrylonitriles designed by juxtaposition of bioactive entities were synthesized in three steps. Firstly, this involves the synthesis of the imidazopyridine core via cyclocondensation. Then,its functionalization at position 2 with an acetonitrile group, and finally condensation of the resulting intermediate with various aromatic aldehydes
Results: A total of ten derivatives of (6-chloroimidazo [1,2-a]pyridin-2-yl)-phenylacrylonitrile were obtained, with yields ranging from 63% to 92%. The biological evaluation focused on the antifungal activity of these compounds against a clinical strain of Candida parapsilosis, with minimum inhibitory concentrations (MIC) ranging from 19.36 µM to 89.38 µM. Structure–activity relationship (SAR) analysis revealed that the nature and position of the substituent on the aryl ring significantly modulate antifungal efficacy. These findings highlight the pharmacochemical relevance of electron-withdrawing or polarizable substituents in enhancing antifungal activity.
Conclusion: Due to their innovative profile combining a functional chain and a bioactive pharmacophore, these novel imidazo[1,2-a]pyridine hybrids appear as promising candidates for the development of potent antifungal agents, particularly against Candida species.
📅 2025
📰 Asian Journal of Chemical Sciences
DOI
Santé Humaine
Épidémiologie et surveillance
Paludisme
Background: Counterfeit and substandard medicines represent a severe public health issue, particularly in developing nations where their prevalence exacerbates disease resistance and economic challenges. In addition, many deaths in Côte d'Ivoire could be avoided each year if the drugs prescribed against malaria were compliant with regulations and able to effectively treat the disease. Objective: This study aimed to evaluate the quality of artemether-lumefantrine antimalarial combination on the Ivorian illicit market using the GPHF-Minilab® kit. Methods: A total of 15 samples were analyzed through visual inspection, disintegration testing, and TLC for qualitative and semi-quantitative assessments. Results: The findings reveal significant non-conformities, including 20% of samples lacking manufacturer information, 7% without accompanying instructions, and 20% with physical degradation. 93% of samples disintegrated within 30 minutes, meeting pharmacopoeial standards. One sample exceeded the recommended time, indicating substandard manufacturing. Most samples (67%) met active ingredient quantity requirements, but 26% were underdosed, and 7% were overdosed, highlighting manufacturing and storage deficiencies. In view of these results, it appears that the Artemether-lumefantrine drugs seized on the illegal market in Côte d'Ivoire are not of good quality. Conclusion: The GPHF-Minilab® proves a reliable tool for identifying substandard and counterfeit drugs in resource-limited settings, though further validation is required for broader applications. These results underscore the need for stringent regulatory frameworks, public education, and expanded quality control initiatives.
📅 2025
📰 International Journal of Pharmacy and Chemistry
DOI
Santé Humaine
Épidémiologie et surveillance
Medicines of lower and falsified qualities (MLFQ) are a real public health problem. They are responsible for some drug resistance to antibiotics and several deaths worldwide. Faced with this scourge, quality control of our country's medicines is essential in order to maintain the quality of medicines and ensure a certain safety for patients. To contribute to the fight against MLFQ, we proposed to use the GPHF-Minilab kit to evaluate the quality of some antibiotic molecules seized on the Ivorian illicit market.
This is a descriptive study with analytical purposes on the quality of illicit drugs seized by the police. Medicinal products presented as containing ceftriaxone or cefixime or ciprofloxacin or ofloxacin were collected and analysed according to the instructions of the GPHF-Minilab.
The analyses carried out on the 24 samples revealed non-conformities, namely unknown origin (12.5%), lack of batch number (12.5%), package leaflet (16.67%), address of manufacturer (58.33%), absence of expiry date (8.33%) and date of manufacture (4.17%), underdosed active ingredients (4%) or over-dosed active ingredients (13%). As these non-conformities are likely to induce misuse, therapeutic failures or even poisoning, the marketing and consumption of such products should be avoided.
The Minilab kit is a relevant, fast, and easy-to-use tool that can contribute to the evaluation of the quality of the drug at checkpoints in our country to fight against this gangrene.
📅 2024
📰 The Pharmaceutical and Chemical Journal