Quinoline core antimalarials are a major class used for the management of uncomplicated malaria in combination with artemisinin derivatives. Moreover,
despite its adverse effects, Quinine remains the reference molecule in the treat-ment of cerebral malaria due to Plasmodium falciparum. This class also contains molecules such as Mefloquine used in the prevention of malaria. In addition,
synthetic derivatives are more manageable with greater therapeutic margins and fewer adverse effects. They have an interest in avoiding the spread of resistance, especially with derivatives possessing gametocytocidal activities. With the presence of a chloroquine-resistant strain of Plasmodium, the use of synthetic derivatives
as monotherapy is prohibited to avoid the spread of resistance in this class. In this chapter, we propose to present the class of antimalarials with a quinoline nucleus under its pharmacochemical aspects as well as the prospects for its development to preserve and improve the effectiveness of its representatives in the management of malaria.
For better management of malaria, WHO recommends early biological diagnosis for rapid treatment. In Côte d'Ivoire, due
to difficulties associated with the use of microscopy in primary health care facilities, the biological diagnosis of malaria
relies mainly on RDTs. Private pharmacies play an important role in the outpatient healthcare using RDTs to diagnose
malaria. The aim of this study was to determine knowledge of patients and frequency of malaria cases using RDTs among
patients in private pharmacies of Côte d’Ivoire. This cross-sectional survey was carried out from June to November 2020
among patients in three private pharmacies. Questionnaire was administered to individuals after informed consent to
assess knowledge and collect sociodemographic data. Blood samples were taken from patients and the "ABON™ Plus
Malaria P.f /Pan" RDT was performed on each sample. Of 450 subjects sampled, 33.3% (150/450) were RDTs positive.
Plasmodium falciparum was the only species identified. The majority of the population (93.4%) revealed that the mode of transmission of malaria is mosquito bites. The main symptom of patients was fever (85.6%). The main ways of malaria prevention mentioned by patients were the use of insecticides (80%) and mosquito nets (73.5%). The majority of patients (74.6%) justified biological confirmation by detecting parasite in blood. This study shows the importance of confirming suspected cases of malaria in all contexts, in order to avoid misuse of anti-malarial drugs in pharmacies.